A teeny, tiny tweak in the Pfizer mRNA injections that U.S. children ages 5 to 11 will be getting is actually a significant difference in formulation that for some reason isn’t being discussed in the media.

The change in ingredients is listed on page 14 of the FDA’s Pfizer briefing document as a “buffer” called tromethamine (Tris), which is intended to provide an “improved stability profile.” It’s already being used in the Moderna shot for older children and adults.

But, what the FDA doesn’t say is that tromethamine (Tris), aka THAM, is a blood acid reducer which is used intravenously to stabilize people with heart attacks and during cardiac surgery.

The FDA said in a news release that Tris is commonly used in other products for children and that it does not present safety concerns but, again, what it doesn’t say is that one of the major roles of Tris in any biological product like vaccine is to increase the permeability of the cell wall.

According to The Journal of Physiology, “Tris in concentrations commonly used as a buffer in physiological salines can exert toxic effects on neuro-muscular transmission in smooth and cardiac muscle though not in skeletal muscle. The effects are variable, mainly presynaptic and appear to affect in particular motor and especially adrenergic transmission. They may be associated with intracellular metabolic actions of Tris.”


Press California October 28, 2021

The Journal of Physiology July 1976

Genetic Education



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